Mechanisms regulating chemokine receptor activity
نویسندگان
چکیده
منابع مشابه
ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology
The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells (LECs) are playing an active role in this context via the expression of chemokines, inflammatory mediators promoting cell migration, and chemokine rec...
متن کاملCorrigendum: ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology
[This corrects the article on p. 691 in vol. 7, PMID: 28123388.].
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The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competi...
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CD44 is a cell surface glycoprotein present on many cell types. Many CD44 isoforms have been identified. All CD44 isoforms utilize identical transmembrane and cytoplasmic domains. The hematopoietic form of CD44 (CD44H) is the major CD44 protein present on normal human lymphocytes and monocytes. One of the ligands for CD44 is hyaluronic acid (HA), a polymer consisting of repeat units of disaccha...
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We have previously shown that members of the ELR(+) CXC chemokine family, including IL-8; growth-related oncogenes alpha, beta, and gamma; granulocyte chemotactic protein 2; and epithelial neutrophil-activating protein-78, can mediate angiogenesis in the absence of preceding inflammation. To date, the receptor on endothelial cells responsible for chemotaxis and neovascularization mediated by th...
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ژورنال
عنوان ژورنال: Immunology
سال: 2011
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2011.03485.x